2,6-Di-tert-butyl-4-methylpyridine

Gusaba
Intungamubiri ngengabihe, intambamyi ikomeye, idafite nucleophilique itandukanya Brnsted (protonic) na acide ya Lewis.Gushoboza guhinduranya umusaruro mwinshi wa aldehydes1 na ketone1,2 kuri vinyl triflates.

2,6-Di-tert-butyl-4-methylpyridine ni ifumbire mvaruganda hamwe na formula ya molekuline C14H23N, intera ikomeye mungingo ngengabuzima, ikoreshwa cyane cyane mu bahuza imiti, synthesis organique, solge organic, nayo irashobora gukoreshwa mugukora amarangi, imiti yica udukoko umusaruro n'impumuro nziza, nibindi
Uburyo bwo gukora
1 g (0.2 mol) ya trimethylethyl phthalide chloride na 3,7 g (0,05 mol) ya tert-butanol.Uruvangitirane rwa reaction rwashyutswe mu bwogero bwamavuta kugeza kuri 85 ° C.Hanyuma g 15 (0.1 mol) ya acide trifluoromethanesulfonic yongewemo muminota irenga 15.Igisubizo cyakomeje mu minota 10, kandi ibicuruzwa byijimye byijimye byakonje mu bwogero bwa barafu hanyuma bisukwa muri ml 100 ya ether ikonje.Imvura yijimye yarayungurujwe irumishwa kugirango ibone 9,6 g (54%) yumunyu watinze..
2. Gutegura 2,6-Di-tert-butyl-4-methyl-vizine Mu kubyutsa, guhagarika g 10 (0,028 mol) yumunyu wa vizine muri 200 mL ya 95% Ethanol yakonje kugeza kuri 60 ° C yari wongeyeho rimwe kuri 100 mL ya ammonia yibanze yakonje kugeza kuri 60 ° C mumashanyarazi ya litiro 1.Igisubizo cyakomeje kuri 60 ° C muminota 30 na 40 ° C mumasaha 2, muricyo gihe ihagarikwa ryaseswa.Hanyuma, imvange ya reaction yasutswe muri ml 500 yumuti wa sodium hydroxide ya 2% yashyutswe buhoro buhoro ubushyuhe bwicyumba.Yakuwe hamwe na .4-100 ml ya pentane, ibivanze hamwe, ml 25 yumuti wuzuye wa sodium chloride wogejwe, ml 100 ya pentane rotary evaporator yibanze.