5-Fluorocytosine

Gusaba
Flucytosine kumunwa ikoreshwa mukuvura indwara zikomeye ziterwa nubwoko bworoshye bwa Candida cyangwa Cryptococcus neoformans.Irashobora kandi gukoreshwa mukuvura chromomycose (chromoblastomycose), mugihe imitsi ishobora gutera kwandura.Flucytosine ntigomba gukoreshwa nkumuntu wonyine mu kwanduza ibihumyo byangiza ubuzima bitewe ningaruka nke za antifungal ndetse niterambere ryihuse ryokurwanya, ahubwo ifatanije na amphotericine B na / cyangwa antifungali ya azole nka fluconazole cyangwa itraconazole.Indwara ntoya nka cystite yanduye irashobora kuvurwa na flucytosine yonyine.Mu bihugu bimwe na bimwe, kuvura hakoreshejwe umuvuduko ukabije w'amaraso mu gihe kitarenze icyumweru na byo ni uburyo bwo kuvura, cyane cyane iyo indwara ishobora guhitana ubuzima.
Indwara zikomeye zifata ibihumyo zirashobora kugaragara mubadafite ubudahangarwa.Aba bantu bungukirwa no kuvura hamwe harimo na flucytosine, ariko impanuka ziterwa ningaruka zo kuvura hamwe, cyane na amphotericine B, zishobora kuba nyinshi.

5-Fluorocytosine ikoreshwa mu kuvura indwara ziterwa na Cryptococcus na Candida, nka fungal sepsis, endocarditis, meningitis, hamwe na antifungal zanduza ibihaha n'inkari.
Ibiranga
Iki gicuruzwa gifite ibikorwa byinshi birwanya antifungal kurwanya Candida spp.na Candida spp.kandi ifite ibikorwa bya antibacterial kurwanya Bacillus spp.na Mycobacterium spp.Igicuruzwa ni antibacterial yibitekerezo bike hamwe na fungicidal yibitekerezo byinshi.Uburyo bwibikorwa nuguhagarika synthesis ya acide nucleic aside.Agahumyo karoroshye kubyara ibicuruzwa.
Kwirinda
Ufatanije na amphotericine B, igira ingaruka zoguhuza, ariko irashobora kugabanya gusohora ibicuruzwa biva mu mpyiko kandi bikongera ubwinshi bwamaraso, bishobora gutera uburozi mumpyiko no mumaraso.Kubwibyo, ubwinshi bwamaraso yibanze bigomba gukurikiranwa no kubungabungwa kuri 50-75μg / ml, bitarenze 100μg / ml;gukoresha imiti igabanya amagufwa irashobora kongera ubumara bwa hematologique bwibicuruzwa.
Ibicuruzwa birashobora gutera ① isesemi, impiswi, guhubuka, nibindi.;Damage kwangiza umwijima, cyane cyane ibipimo byerekana imikorere yumwijima, ariko na hepatomegaly cyangwa na necrosis ya hepatike;El myelosuppression leukocyte no kugabanya platine, rimwe na rimwe birashobora gutera amaraso cytopenia yose.Ibura rya granulocytic leukocyte ryica no gukuraho amaraso make nabyo byavuzwe;④ salusiyo, kubabara umutwe na vertigo nabyo byavuzwe.Noneho rero, koresha witonze kubarwayi bafite ubumuga bwumwijima cyangwa impyiko, indwara zamaraso, hamwe no guhagarika amagufwa.Ishusho yamaraso ya peripheri, imikorere yumwijima nimpyiko hamwe na gahunda yinkari bigomba kugenzurwa buri gihe mugihe ukoresheje iki gicuruzwa.Ifite teratogenic mu gupima inyamaswa, kandi igomba gukoreshwa ubwitonzi ku bagore batwite.
Ingaruka mbi zirimo transaminase nyinshi, fosifata ya alkaline, ibimenyetso bya gastrointestinal, leukopenia, anemia, trombocytopenia, ubumuga bwimpyiko, kubabara umutwe, kugabanuka kwamaso, salusitike, kutumva neza, dyskinesia, kugabanuka kwa potasiyumu, calcium na fosifore, hamwe na allergique (urugero: rash) .