Dexamethasone

Gusaba
Ikoreshwa cyane cyane muri anti-inflammatory na anti allergic.Irakwiriye kurwara rubagimpande nizindi ndwara za kolagen.

Dexamethasone (DXMS) yashizwemo bwa mbere mu 1957 kandi ishyirwa ku rutonde rwa OMS y’ubuvuzi bukuru bwa OMS nkimwe mu miti yingenzi ya sisitemu yubuzima rusange.
Ku ya 16 Kamena 2020, OMS yavuze ko ibyavuye mu isuzuma ry’amavuriro mu Bwongereza byerekanye ko dexamethasone ishobora kurokora ubuzima bw’abarwayi bafite umusonga ukabije wa neocoronary, bikagabanya impfu zigera kuri kimwe cya gatatu cy’abarwayi bari bahumeka ndetse na kimwe cya gatanu cy’abarwayi bari kuri ogisijeni gusa.
Dexamethasone ni corticosteroid yubukorikori ishobora gukoreshwa mu kuvura indwara zitandukanye, harimo indwara zifata rubagimpande, indwara zimwe na zimwe z’uruhu, allergie ikabije, asima, indwara zidakira zifata ibihaha, indwara laryngite ikiranuka, ubwonko bw’ubwonko, kandi birashoboka ko ifatanije na antibiotike ku barwayi bafite igituntu.Ifite igipimo cyo gutwita cya C muri Amerika, bisaba isuzumabumenyi ko imikorere y’ibiyobyabwenge iruta ingaruka mbi mbere yuko itangwa, hamwe na A muri Ositaraliya, byerekana ko ikunze gukoreshwa ku bagore batwite kandi ko nta kimenyetso cyerekana ko umwana yangiritse.

Ingaruka za farumasi
Dexamethasone, izwi kandi nka flumethasone, fluprednisolone, na dexamethasone, ni glucocorticoid.Ibikomokaho birimo hydrocortisone, prednisone, nibindi. Ingaruka za farumasi zirwanya cyane cyane anti-inflammatory, anti-toxic, anti-allergic na anti-rheumatic, kandi ikoreshwa cyane mubikorwa byubuvuzi.Plasma yayo T1 / 2 ni iminota 190 naho tissue T1 / 2 ni iminsi 3.Umubare munini wamaraso ya dexamethasone sodium fosifate cyangwa acetate ya dexamethasone igera kumasaha nisaha 8 nyuma yo guterwa inshinge.Igipimo cya plasma protein ihuza iki gicuruzwa kiri munsi yizindi corticosteroide.Igikorwa cyo kurwanya inflammatory ya 0,75 mg gihwanye na mg 5 za prednisolone.Adrenocorticosteroide, anti-inflammatory, anti-allergique na anti-toxic birakomeye kuruta ibya prednisone, kandi ingaruka zo kugumana sodium no gusohora potasiyumu ziroroshye cyane.
1. Ingaruka zo kurwanya inflammatory: Irashobora kugabanya no gukumira ingirabuzimafatizo zitera umuriro, bityo bikagabanya kwigaragaza.Imisemburo ibuza kwirundanya kwingirangingo, harimo macrophage na leukocytes, ahakongoka kandi ikabuza fagocytose, kurekura imisemburo ya lysosomal, hamwe no gusohora no kurekura abunzi ba chimique yumuriro.
2. Ingaruka zo gukingira indwara: harimo gukumira cyangwa guhagarika ibisubizo by’ubudahangarwa bwakorewe mu ngirabuzimafatizo, gutinda kwa allergique, kugabanya umubare wa Lymphocytes T, monocytes, na eosinofile, kugabanya ubushobozi bwo guhuza immunoglobuline ku byakira selile, no kubuza guhuza no kurekura interleukine. , bityo kugabanya ihinduka rya Lymphocytes T na lymphoblasts no gushimangira kwaguka kwimikorere yibanze yumubiri.Igabanya kunyura mubice byubudahangarwa binyuze muri membrane yo munsi kandi bigabanya kwibumbira hamwe byuzuzanya hamwe na immunoglobuline.
Ihita yinjira mumashanyarazi ya GI, hamwe na plasma T1 / 2 yiminota 190 hamwe na tissue T1 / 2 yiminsi 3.Ubwinshi bwamaraso bugera kumasaha 1 namasaha 8 nyuma yo guterwa inshinge zo mu bwoko bwa sodium fosifate ya dexamethasone cyangwa acetate ya dexamethasone.Igipimo cya plasma protein ihuza iki gicuruzwa kiri munsi yizindi corticosteroide, kandi ibikorwa byo kurwanya inflammatory 0,75 mg bihwanye na mg 5 za prednisolone.