Acide Polyinosinic Acide-polycytidylic Acide

Gusaba
Poly I: C izwiho gukorana na reseptor 3 yishyurwa (TLR3), igaragarira kuri endosomal membrane ya B-selile, macrophage na selile dendritic.Poly I: C isa na RNA ifite imirongo ibiri, igaragara muri virusi zimwe na zimwe kandi ni "kamere" itera TLR3.Rero, Poly I: C irashobora gufatwa nkigereranya rya RNA ikubye kabiri kandi nigikoresho rusange cyubushakashatsi bwa siyansi kuri sisitemu yumubiri.

Ibiranga
Iki gicuruzwa ni inducer ya syntetique interferon, ikaba polyribonucleotide ikubye kabiri igizwe na aside polyinosinike na aside polycytidylic.Kubera ko interferon yihariye ubwoko, biragoye gutegura ubwinshi bwogukoresha amavuriro, kubwibyo bikoreshwa cyane nka inderereri ya interferon kugirango itere interferon.Byongeye kandi, aside polyinosinike iracyafite uruhare rwo gukingira indwara, ishobora gukangura sisitemu ya reticuloendothelia, kongera imikorere ya fagocytike ya fagocytes, kongera imiterere ya antibodies, gutera allograft reaction no gutinda kwa allergique.Ifite imiyoboro yagutse ya virusi na antitumor.

Gukoresha hamwe na synthesis
Incamake
Acide Polycytidylic, izwi kandi nka acide polyinosinike, nucleotide ya polyhypoxanthine na nucleotide ya polycytidine, ni imwe mu mikorere ya polynucleotide, igizwe n’urunigi rwa polinucleotide ikubye kabiri ya aside polyinosinike na aside polycytidylic, hamwe no gushonga kuri -20 ℃ .

Ingaruka za farumasi
1. Acide polyinosinike igira ingaruka nziza zo kuzamura ubudahangarwa bwihariye kandi budasanzwe bwumubiri.
(1) Polymyocytes yongerera imbaraga ingirabuzimafatizo
(2) Polymyocytes iteza imbere gusohora cytokine zitandukanye
(3) Kwinjiza poroteyine ya Mx na polymyocytes
(4) Polymyocytes iteza imbere gukora antibodies muri vivo

2. Ingaruka zo kurwanya virusi ya polymyocytes
Mu bizamini bya vitro, ibizamini by’inyamaswa n’ibizamini by’amavuriro byerekanye ko polymyxine igira ingaruka zitandukanye za virusi, harimo virusi y’umuhondo, virusi ya encephalomyelitis, virusi ya Rift Valley, virusi y’ibicurane by’ibiguruka, virusi ya hepatite, virusi ya sida, ibirenge n'umunwa. virusi yindwara, virusi ya conjunctivitis, virusi yoroshye ya rash, virusi ya Mengo, virusi ya pox, virusi ya myocarditis, virusi ya Aleutian, coxsackievirus, nibindi. Byaragaragaye ko ingaruka zo gukumira Polymyxa ari nziza kuruta ingaruka zo kuvura virusi.

Gusaba
1.Umugozi wa homopolymer wikubye kabiri ushobora gukoreshwa nkicyitegererezo RNA mukwiga ibimenyetso byerekana selile kurwego rwa TLR3 kumenya RNA ikubye kabiri, nayo ikaba ari yo ntandaro yo gukingira indwara ziterwa na virusi.

2.Yakozwe na acide polyinosinike kugirango ikore selile polyinosinic, ikoreshwa mukuvura hepatite ya virusi, herpes zoster, herpes simplex keratitis, herpes stomatitis, icyorezo cya hemorhagasi, nibindi.

3. Ifite ubudahangarwa bw'umubiri, itera sisitemu ya reticuloendothelial, ikongera fagocytose, ikongera antibody, igatera allograft reaction kandi igatinda allergie.Ifite imiyoboro yagutse ya antiviral n'ingaruka za antitumor.Ahanini ikoreshwa mubuvuzi: kwirinda cyangwa kuvura indwara zanduye, kuvura herpes zoster, herpetic keratitis, hepatite ya virusi.Kuvura ibibyimba.Ingaruka mbi zirimo cyane cyane hypothermia yinzibacyuho hamwe nabantu bafite umuriro mwinshi hejuru ya 38 ℃, ahanini bigabanuka bonyine muminsi 1-2.Niba umuriro utagabanutse muminsi 2, imiti igomba guhita ihagarikwa.Intege nke, umunwa wumye, kuzunguruka, isesemi, nibindi nabyo biragaragara.