Ibicuruzwa
3,3'- diindolylmethane
Ibisobanuro
3,3'-diindolylmethane ni imiti ya farumasi;Irashobora kuboneka muri phytochemiki karemano yibimera bya Cruciferae, aside catalizike yibicuruzwa, indole-3-methanol;Ifite imikorere yo kurwanya ibibyimba;Mugihe ibintu byibanze cyane, ibiyikomokaho ntibishobora kwihutisha gusa apoptose yingirangingo za kanseri yabantu, ariko kandi binakangurira inzira gutera apoptose ya selile ya kanseri yabantu;Chemicalbookdim itera ingirabuzimafatizo ya G1 muri kanseri y'ibere ya MCF-7 ikoresheje uburyo no kwerekana imvugo;Dim ni inhibitor ikomeye ya mitochondrial h + -pase;Nkumushinga mushya wo guteza imbere ibihingwa, dim n'ibiyikomokaho byakoreshejwe mubushakashatsi bwangiza ibidukikije.
Amakuru y'ibicuruzwa
Cas No ： 1968-05-4
Isuku ： ≥98%
Inzira ： C17H14N2
Amata Wt.： 246.31
Izina ryimiti ： 3,3'-Diindolylmethane
Synonym ：: 3,3'-Diindolylmethane (DIM); Di (1H-indol-3-yl); Igiterwa: Indole; 3,3'-DIINDOLYLMETHANE,> = 98% (HPLC); 3,3'-METHYLENEBIS- 1H-INDOLE; 3,3'-METHYLENEBISINDOLE; 3,3'-METHYLENEDIINDOLE; 3,3'-DIINDOLYLMETHANE
Ingingo yo gushonga ： 167 ° C.
Ingingo yo guteka ： 230 ° C.
Gukemura ： Chloroform (Buke), Methanol (Buhoro)
Kugaragara powder Ifu yera
Kohereza no kubika
Ububiko butajegajega busabwa ubushyuhe bwo kubika -20 ° C.
Gutegura Shyira indole (1,17 g, mm 10 mm), CTAB (50% mol) na aside ya oxyde (50% mol) muri ml 25 ml imwe yizosi ryizengurutse-flask, ongeramo ml 5 ya deionion, ukangure neza muminota 5 hanyuma hanyuma ongeramo igisubizo cyamazi ya formaldehyde (0.38 g igisubizo, 5 mmol formaldehyde) itonyanga.Reba kuri 3 h mubushyuhe bwicyumba hanyuma uhagarike reaction.Igisubizo cya reaction cyakuwe hamwe na ml 15 ya Ethyl acetate mubice bitatu, hanyuma icyiciro kama kirakusanywa hanyuma cyumishwa na Anhydrous Na2SO4 mumasaha 5.Umuti wakuweho kubera umuvuduko ukabije hanyuma usubirwamo ushyizwe mu ruvange rwa methanol n’amazi (methanol / H2ChemicalbookO = 10/1) kugirango utange umweru wera 3,3'-diindolylmethane mu musaruro wa 85%.Bioactivite3,3'-Diindolylmethane (DIM) nigicuruzwa nyamukuru cyigogora cya indole-3-karbinol, kikaba ari ikintu gishobora kuba anticancer mu mboga zibisi.3,3'-Diindolylmethane (DIM) ni antagonist ikomeye ya androgenreceptor (AR) .
Mu bushakashatsi bwa vitro bwerekanye ko DIM ari radioprotector na mitigator ikora neza, ikora mugukangurira ATM itwarwa na DDR imeze kimwe na NF-κB ibimenyetso byo kubaho. nka AKT, NF-κB na FOXO3.Irashobora kandi kubuza imvugo ya estrogene iterwa na gene kandi igatera endoplasmic reticulum.chimiqueDIM irashobora guhindura metabolism ya estrogene kandi ikarwanya ibikorwa bya estrogene na reseptor.Muri vivo ubushakashatsi bwerekanye ko DIM ikora neza kurwanya imirasire ya sisitemu nyuma yubuyobozi bwinshi.Mu bizamini bya vivo, DIM yatanze kurinda imirasire cyangwa kugabanya.Mubice bisanzwe, DIM ikora ATM.dIM irashobora gutangwa ku mbeba mukuzuza umunwa (250 mg / kg) hamwe na bioavailable nyinshi kandi nta t ikaze t
